All the Office 365 email clients include an out-of-office assistant that responds to incoming messages with a note from you. When you use this feature, you have the option of enabling it at various levels.
If you are having problems with your email, one common diagnostic aid is a complete list of the message's headers. Headers show the path a message took to get from the sender to the recipient. The IT Service Desk or other technical support may ask you to provide a message's headers.